GPCR networks

GPCR Interaction Network

GPCR networks
HetNet NonHetNet

Search protomer by UniProt name

About us

This web site was developed and designed by:

Ismel Brito Rodriguez,
Dasiel Oscar Borroto Escuela, and
Kjell Fuxe.

We would like to thank Michael Di Palma for his support in bibliographic reference gathering.

If you encounter any difficulties as you use it or have any comments, please send us your feedback to Dasiel.Borroto-Escuela (at) ki (dot) se.

Instructions

Welcome to the GPCR Interaction Networks!

This web site has been designed to visualize GPCR interaction networks. We distinguish between two types of interaction networks: HetNet and NonHetNet. In the former each receptor is a network node and every line between two receptor means that these two connected receptors interact between them according to consulted literature. In the latter network, however, every dotted line means that the two connected receptors does not interact. In the site you can visualize one of these two networks by clicking on the buttons that appear in the top-left panel as you can see below.

netButtons

You might also be interested in seeing the interaction and non-interactions of a specific receptor (let's call it the target receptor). We provide you two ways to achieve this.

You might use the search input box that appears in the top-left panel. This is an autocomplete input box so you don't need to type the whole receptor name to find the target receptor. It worth mentioning that we use UniProt receptor name in search. Please visit Uniprot site to find out the proper receptor name.

searchBox

Alternatively, if you see the target receptor in the network, you can click on it.

In both cases a new subnetwork is drawn in which the target receptor and its interactions/non-interactions are shown.

The site also contains three other panels. In the bottom-left panel we show the map between receptor families and network node colours. In the bottom-right corner we provide some topological properties of the network being shown.

The top-right panel is not always visible. It only provides information about a subnetwork for a given target receptor. For every receptor in the subnetwork we enlist the bibliographic references that claim the fact that it does/doesn't interact with the target receptor.

referenceList

For instance, the image above shows the reference list in the HetNet subnetwork for GIPR receptor.

Network topology

Show all families

GPCR Interaction Network

Network topology

Protomer families